question
Produced inside certain bacteria as part of normal growth; secreted into the surrounding medium or released after lysis.
answer
Exotoxin
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Antibiotics may cause _______ release and make disease symptoms worse; then disease improves as _______ is broken down.
answer
Endotoxin
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Genes for most ________ are carried on plasmids or phages.
answer
Exotoxin
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May produce miscarriage and activate blood clotting.
answer
Endotoxin
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______ are proteins; many are enzymes.
answer
Exotoxin
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Can inactivate _____ by heat/chemical treatment and inject these TOXOIDS as a vaccine (e.g. diphtheria and tetanus vaccines)
answer
Exotoxin
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Disease results from ______, not from the bacteria
answer
Exotoxin
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Outer membrane consists of lipopolysaccharides (LPS). The lipid portion of LPS is called lipid A, an ________!
answer
Endotoxin
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Small LD50
answer
Exotoxin
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Does NOT produce a fever
answer
Exotoxin
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________ are part of the outer portion of the cell wall in gram-negative bacteria. (Recall that gm-neg bacteria have an "outer membrane" that surrounds the peptidoglycan layer.)
answer
Endotoxin
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Released when bacteria die, their cell walls are lysed, and the _______ is liberated.
answer
Endotoxin
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_________ stimulate macrophages to release cytokines at high levels that are toxic.
answer
Endotoxin
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All _______ produce the same signs and symptoms (to varying degrees): chills, fever, weakness, generalized aches, and sometimes shock and death.
answer
Endotoxin
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________are some of the most lethal substances known (e.g. botulinum toxin)
answer
Exotoxin
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Produces fever
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Endotoxin
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Large LD50
answer
Endotoxin
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Bacteria that produce ______ may be gram-negative or gram-positive (mostly gram-positive).
answer
Exotoxin
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NOT neutralized by an antitoxin
answer
Endotoxin
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Body produces antibodies called ANTITOXINS; provide immunity
answer
Exotoxin