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guides to consider when reading a clinical journal
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the title
the author
the summary
the site
the author
the summary
the site
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Consistency of findings
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consistency of findings in different populations and in different countries strengthens the inference of causation
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time order
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amount of time between exposure and onset of disease
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dose-response gradient
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the greater the exposure the stronger the effect
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biological plausibility
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established from animal studies
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specificity of association
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an association is specific when a certain exposure is associated with only one disease
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Odds Ratio (OR)
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way of presenting probabilities
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factors for width of confidence intervals
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- sample size
- variability of the characteristics being studies
- degree of confidence required
- variability of the characteristics being studies
- degree of confidence required
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latency or incubation
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between the time the infection occurs and the appearance of clinical symptoms
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specific etiology
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each disease has a particular cause
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endemic
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native or confined to a particular region or people
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hypoendemic
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an endemic disease that affects a small proportion of the population at risk
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Hyperendemic
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at an especially high level of continued incidence in a population
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Incidence and Prevalence
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number of cases of a specific health disorder occurring within a given pop during a stated period of time
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disease prevalence
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It is the number of all cases of a disease (both old and new) that are identified in a specific population at a given point in time.
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Incidence vs. Prevalence
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incidence = rate at which cases first appear
prevalence = rate at which all cases exist
prevalence = rate at which all cases exist
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causation in health research
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fundamental task of health research is to investigate causation
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multiple causality
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requirement that more than one factor be present for disease to develop
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The Concept of Multicausality
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each effect has a number of causes and each cause can produce a a number of effects
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conditions for a causal relationship
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- co-variation
- temporal precedence
- temporal precedence
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Co-variation
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X and Y are associated over space and time
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temporal precedence
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X comes first in time, before Y
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reasons for causal models
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- there may be a true causal relationship
- the association may occur simply by chance
- X may co-vary with Y because of some third variable Z
- the association may occur simply by chance
- X may co-vary with Y because of some third variable Z
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BMD thesis
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disease causation is biologically specific
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mechanistic view of the body
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demonstrated that diseases could be produced by the intro of single specific factors
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BMD view of disease
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disease is a temporary or permanent impairment in the functioning of any single component, or of the relationship between the components making the individual
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assumptions of the biomedical disease model
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- disease as a deviation from normal biological functioning
- the doctrine of specific etiology
- diseases are generic: universal to human species
- scientific neutrality and rationality
- medical fashion is thought to develop and progress in a linear fashion
- the doctrine of specific etiology
- diseases are generic: universal to human species
- scientific neutrality and rationality
- medical fashion is thought to develop and progress in a linear fashion
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Limits of biomedicine
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- concentration on individual
- focus on component parts of the body
- focus on component parts of the body
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social construction of health
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The very notion of health is socially constructed and variable across populations and across time.
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approaches to explain geographies of health
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- positivist
- social constructionist - humanistic
- structuralist
- structurationist
- post-structuralist
- social constructionist - humanistic
- structuralist
- structurationist
- post-structuralist
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Positivist Approach
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seeks to establish testable hypotheses like natural sciences
- observable
- measurable
- generalizable
- observable
- measurable
- generalizable
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social constructionist - humanisitc
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address human beliefs, values, meanings, intentions
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Symbolic Interactionism
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Study how the subjective definitions of social reality are constructed and how this reality is experienced and described by the social actors
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Structuralist Approach
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focuses on how underlying causes of disease and illness are embedded in political and economic systems
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conflict theory
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all knowledge is rooted in social, material, and historical context
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structurationist approach
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one set of alternatives to positivist explanation gives greater weight to the lives of real people "human agency"
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Structuration Theory
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a general framework that explains how people use rules and resources to interact in a social system
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Post structuralist approach
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perspectives are concerned with how knowledge and experience are constructed in the context of power relations
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spatial diffusion of disease
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Diffuse defined as "to disperse or be dispersed from a centre; to spread widely, disseminate
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Expansion Diffusion
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process whereby a phenomenon of interest spreads from one place to another
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relocation diffusion
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a spatial spread process, but the items being diffused leave the area where they originated as they move to new areas
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types of expansion diffusion
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Hierarchical, contagious, and stimulus.
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contagious spread
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depends on direct contact
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hierarchical spread
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involves transmission through an ordered sequence of classes or places
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stages of diffusion waves
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- primary stage
- diffusion stage
- condensing stage
- saturation stage
- diffusion stage
- condensing stage
- saturation stage
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primary stage
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marks the beginning of the diffusion process
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Diffusion stage
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signals the start of the actual spread process
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condensing stage
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relative increase in the numbers accepting an item is equal in all locations, regardless of their distance from the original
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saturation stage
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marked by a slowing and eventual cessation of the diffusion process, which produces a further flattening of the acceptance curve
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Epidemics of communicable diseases
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- propagated epidemic
- common-vehicle epidemic
- common-vehicle epidemic
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propagated epidemic
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one that results from the chain transmission of some infectious agent
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common-vehicle epidemic
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results from dissemination of a causative agent
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reasons why measles is a tracker epidemic disease
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- virological
-epidemiological
- clinical
- statistical
- geographical
- mathematical
- humanitarian
-epidemiological
- clinical
- statistical
- geographical
- mathematical
- humanitarian
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virological reasons for measles as tracker
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measles has been referred to as the simplest of all the infectious disease by WHO
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epidemiological reasons for measles as tracker
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measles exhibits very distinctive wavelike behaviour
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clinical reasons for measles as tracker
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disease can be ready identified with its distinctive rash and the presence of Koplik spots with the mouth
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statistical reasons for measles as tracker
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high rate of incidence leads to a very large number of cases over a short period of time to give a distinct epidemic event
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geographical reasons for measles as tracker
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disease is as widespread as a human population itself is in the early 21st century
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humanitarian reasons for measles as tracker
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despite major falls in mortality over this century, it still remains a major killer
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the simplest form of an epidemic model
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Hamer-Soper model
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Kendall and spatial waves
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relationship between the input and output components in the wave generating model has shown to be critical
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Wave 1 of Kendall and spatial waves
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approximates that of the normal curve
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Wave 2 of Kendall and spatial waves
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occupies an intermediate position and is included to emphasize that the changing waveforms are examples from a continuum
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Wave 3 of Kendall and spatial waves
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generated when the susceptible population is well above the threshold value
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questions asked related to disease diffusion process
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1. can we identify what is happening and why?
2. what will happen in future?
3. what will happen in future if we intervene in some specified way?
2. what will happen in future?
3. what will happen in future if we intervene in some specified way?
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net productive ratio
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Basic reproductive ratio for a finite period of time of the pathogen in the host pop when resources (hosts) are not limiting
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effective reproductive ratio
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average number of 2degree cases per primary case after pathogen is established
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Temporal patterns of disease
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- incidence endemic
- regular basis epidemic
- regular basis epidemic
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herd immunity
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The resistance of a group to an attack by a disease to which a large proportion of the members of the group are immune
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concepts of health
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- biomedical
- ecological
- psychosocial
- holistic
- ecological
- psychosocial
- holistic
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Nursing View of Health
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takes a holistic view of health, one of multidimensionality
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nursings main conceptual areas of health
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- intrapersonal
- interpersonal
- extrapersonal
- metapersonal
- interpersonal
- extrapersonal
- metapersonal
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WHO: Ottawa Charter
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- Gave us broader understanding of health promotion
- Shift in focus from individual risk factors to addressing context and meaning of health actions (determinants)
- Primary healthcare (where health promotion/disease prevention occur)
- Inputs to outcomes (Government held accountable)
- The process of enabling people to increase control over and to improve they own health
- Shift in focus from individual risk factors to addressing context and meaning of health actions (determinants)
- Primary healthcare (where health promotion/disease prevention occur)
- Inputs to outcomes (Government held accountable)
- The process of enabling people to increase control over and to improve they own health
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Holistic health movement
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popular middle-class american phenomenon
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shifts in Canadian concepts
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- Lalonde reports
- beyond health care
- the mandala of health
- epp report
- beyond health care
- the mandala of health
- epp report
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Lalonde Report
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importance of lifestyle and environmental factors
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beyond health care
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Conference in toronto which shifted canadian and international public health thinking towards the idea of health as a collective concept
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mandala of health
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A model of the human ecosystem; attempt to better understand the determinants of health.
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epp report
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Achieving Health for All: A Framework for Health Promotion
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the health conundrum
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Many People expect our health system to improve everybody's health, and in the long run reduce morbidity and costs
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reasons for conundrum
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- technical
- medicalization
- demographic
- enviropathic
- administrative
- medicalization
- demographic
- enviropathic
- administrative
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technical reason for health conundrum
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Detection vs treatment: we can detect more than we can successfully treat
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medicalization reason for health conundrum
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Iatrogenesis -over- and misapplication of biomedicine: when applied to problems it cannot solve, it can create morbidity
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demographic reason for health conundrum
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Increased life expectancy related to the epidemiologic transition - tremendous burden of chronic care
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enviropathic reason for health conundrum
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Belief in environmental causes of illness can create emotional impacts
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administrative reason for health conundrum
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Haven't measured the performance of the system well. Getting better at it
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Bottom line of the biomedical approach
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does not adequately explain health phenomena experienced by our society