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M. Tuberculosis is what type of bacillus?
answer
-fastacid
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growth of M. Tuberculosis
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slow growth (generation time = 12 hours)
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M. Tuberculosis resistance
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drying, disinfectants, and low/high pH
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Genus Mycobacterium contains...
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mycolic acids (fatty acids)
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Myopic acids linked to
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arabinogalactan
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what is arabinogalacton and where is it found?
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a polysaccharide linked peptidoglycan; mycobacterium
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signs and symptoms of a respiratory pathogen
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fever, weight loss, cough with bloodied sputum, chest pain, chills
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incubation periods for respiratory pathogen
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2-12 weeks
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latent tuberculoses
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asymptomatic, not contagious
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active tuberculosis
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symptomatic, can transmit bacteria
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reactivation tuberculosis
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renewed growth after latent perio
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Step one of pathogenesis
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inhalation of aerosol that contains bacteria
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Pathogenesis: after inhaling bacteria... (step 2)
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infection, lesion of lower respiratory tract
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Pathogenesis: after infection... (step 3)
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"Latent", bacteria/lesions may be detected, no symptoms
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Pathogenesis: after bacteria may be detected....
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reactivation; goes to "active", symptoms begin and spreads via cough
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bacteria are attacked in lungs by...
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macrophages
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macrophages release...
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signals to recruit other white blood cells
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what forms with bacteria, macrophages, and other immune cells
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tubercle
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healthy patients with walled off tubercles...
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infection turns latent
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Mantoux test aka
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PPD test
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mantoux test
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injection of bacterial protein
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what would a positive TB test indicate?
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vaccinated against TB, encounter the bacteria before, potential latent form in the lungs
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TB Combination therapy
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isoniazid, rifampin, rifapentine
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isoniazid
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inhibit mycelia acid synthesis
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rifampin
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inhibit RNA polymerase
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rifapentine
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inhibits RNA polymerase
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XDR-TB
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extensive drug resistance